Advances in dental bioengineering and their application in orthodontics and dento
Dental bioengineering stem cells gen therapy
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The advances in dental bioengineering disclose the importance of genetic, cellular and tissue therapies as the latest approach to the regenerative medicine for biomechanical orthodontic and dentofacial orthopedics; extending its scope, correcting structural flaws and offering biological alternatives with high quality technology for specialist practices. In this review, some recent findings related to genetic advances in dental bioengineering are provided and applied to the induction of the potential cell forming in the craniofacial complex and its clinical applications. A special research was made using some databases such as: Scopus, Medline and Science Direct, with the following keywords: Bioengineering, Stem cells, and Gen therapy. Finally, we can conclude that the focus of dental practice is led to regenerative medicine as a conventional, innovative and high quality therapy, giving closely results to natural human biology, long term effectivity and less adverse effects. Then we can scope out the vision of all clinic procedures limits with all patients.
Caicedo, C. J., & Villareal, M. P. (2017). Advances in dental bioengineering and their application in orthodontics and dento. Revista Estomatología, 25(1), 32–42. https://doi.org/10.25100/re.v25i1.6417
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2. Li J, Liu D, Zhang F, Wang F, Zhang W, Zhang Z. Human Dental Pulp Stem Cell is a Promising Autologous Seed Cell for Bone Tissue Engineering. Chinese Medical Journal. 2011;124(23):4022-4028
3. Yelick PC, Vacanti J. Bioengineered Teeth from Tooth Bud Cells. The Dental Clinics of North America. 2006; 50(2):191-203.
4. Wise GE, King GJ. Mechanisms of Tooth Eruption and Orthodontic Tooth Movement. Journal of Dental Research. 2008; 87(5):414-34
5. Hiroshi E, Wataru S, Masahiro N, Ikiru A,
Kentaro A. Stem Cells in Dentistry – Part I: Stem Cell Sources: Review. Journal of Prosthodontic Research. 2012;56: 151-65.
6. Hiroshi E, Wataru S, Masahiro N, Ikiru A, Kentaro A. Stem cells in dentistry – Part II: Clinical Applications: Review. Journal of Prosthodontic Research. 2012;16 :229-48.
7. Muñoz W, Trainor P. Neural Crest Cell Evolution: How and When Did a Neural Crest Cell Become a Neural Crest Cell. Current Topics in Developmental Biology. 2015; 111:3-26.
8. Noce, M; Mele, K; Tirino, V; Paino, F. Rosa, A; Naddeo, P; Papagerakis, P; Papaccio, G; Desiderio V. Neural Crest Stem Population in Craniomaxillofacial Development and Tissue Repair. European Cells and Materials. 2014; 28:348-57.
9. Mohanty P, Prasad N, Sahoo N, Kumar G, Mohanty D, Sah S. Reforming Craniofacial Orthodontics Via Stem Cells. Journal of International Society of Preventive and Community Dentistry. 2015; 5(1):13-8.
10. Parada C. Evolución y Desarrollo Facial: Perspectiva Molecular. Universitas Odontológica. 2009; 28(61): 75-85.
11. Hall BK. The Induction of Neural Crestderived Cartilage and Bone by Embryonic Epithelia: an Analysis of the Mode of Action of an Epithelial-mesenchymal Interaction. Journal of Embryology and Experimental Morphology. 1981; 64:305-320
12. Ten R. The Experimental Investigation of Odontogenesis. Journal Developmental Biology. Faculty of Dentistry. 1995; 39:5-11.
13. Kushnerev E, Yates J. Stem Cells in Dentistry – A New Era on the Horizon? Faculty Dental Journal. 2016; 7(2):64-7.
14. Mohammed S, Siar C. Differential Expression of Stem Cell-like Proteins in Normal, Hyperplastic and Dysplastic Oral Epithelium. Journal of Applied Oral Science. 2015; 23(1):79-86.
15. Snider TN, Mishina Y. Cranial Neural Crest Cell Contribution to Craniofacial Formation, Pathology, and Future Directions in Tissue Engineering. National Institutes of Health. 2014; 102(3): 324-332
16. Bunnell B, Flaat M, Gagliardi C, Patel B, Ripoll C. Adipose-derived Stem Cells: Isolation, Expansion and Differentiation. National Institutes of Health. 2008; 45(2): 115-20.
17. Yao S, Pan F, Prpic V, Wise GE. Differentiation of Stem Cells in the Dental Follicle. Journal of Dental Research. 2008; 87(8):767-71.
18. Yanding Z, YiPing C. Bioengineering of a Human Whole Tooth: Progress and Challenge. Cell Regeneration. 2014;3-8.
19. Rocha R. Expanding Therapeutic Boundaries: Stem Cells and Tissue Engineering. Dental Press Journal of Orthodontics. 2011; 16(5):17-9.
20. Mérida I. Bioingeniería y su Aplicación en la Ortodoncia. Revista Latinoamericana de Ortodoncia y Odonotopediatría. 2011.
21. Jasso G, Adalpe B. Bioingeniería Dental ¿El Futuro de la Terapia en Odontología? Revista Asociación Dental Mexicana. 2011; 68(4): 169-74.
22. Hynes K, Menichanin D, Bright R, Ivanovski S, Hutmacher D, Gronthos S, Bartold P. Induced Pluripotent Stem Cells: A New Frontier for Stem Cells in Dentistry. Journal of Dental Research. 2015; 94(11): 1508-15.
23. Margarita D, Diekwisch T, Fincham A, Lau E, McDougall M, Moradian J, Simmer J, Snead M, Slavkin H. Control of Ameloblast Differentiation. Special Review. The International Journal Developmental Biology. 1995; 39(1): 69-72.
24. Zhao H, Chai Y. Stem Cells in Teeth and Craniofacial Bones. Journal of Dental Research. 2015; 94(11): 1495-501.
25. Atalayin C, Tezel H, Dagci T, Karabay Y, Oktem G. Medium Modification with Bone Morphogenetic Protein 2 Addition for Odontogenic Differentiation. Brazilian Oral Research. 2016; 30(1):1-9
26. Carrillo N, García D, Otero L. Aislamiento y Capacidad de Osteodiferenciación de las Células Madre Provenientes del Ligamento Periodontal y Pulpa Dental. Revista CES Odontología. 2015; 28(2): 20-34.
27. Arechaga J. The Tooth as a Model in Organogenesis. An Interview with Professor Harold C. Slavkin. The International Journal of Developmental Biology. 1995; 39(1):13-23.
28. Dabas A, Dabas N, Prabhakar M, Sidhu M. Regenerative Dentistry: A Journey From Stem Cell To A Bio-Tooth. Indian Journal of Dental Sciences. 2013; 5(1).
29. Volponi A, Gentleman E, Fatscher R, Pang Y, Gentleman M, Sharpe P. Composition of Mineral Produced by Dental Mesenchymal Stem Cells. Journal of Dental Research. 2015; 94(11) 1568-74.
30. Volponi A, Kawasaki M, Sharpe P. Adult Human Gingival Epithelial Cells as a Source for Whole-tooth Bioengineering. Research Reports. International & American Associations for Dental Research. 2013; 92(4):329-34.
31. Gao Z, Hu L, Liu G. Bio-Root and Implant-Based Restoration as a Tooth Replacement Alternative. Journal of Dental Research. 2016; 95(6) 642-9.
32. Boke F, Gazioglu C, Akkaya S, Akkaya M. Relationship Between Orthodontic Treatment and Gingival Health: A Restrospective Study. European Journal of Dentistry. 2014; 8(3): 373-80.
33. Alfuriji S, Alhazmi N, Alhamkan N, Ehaideb A, Alruwaithi M, Alkatheeri N, Geevarghese A. The Effect of Orthodontic Therapy on Periodontal Health: A Review of the Literature. International Journal of Dentistry. 2014; 139(4): 413-22.
34. Wise G, Frazier S, Souza R. Cellular, Molecular, and Genetic Determinants of Tooth Eruption. Critical Reviews in Oral Biology & Medicine. 2002; 13(4): 323-34.
35. Ajlan S, Ashri N, Aldahmash A, Alnbaheen M. Osteogenic Differentiation of Dental Pulp Stem Cells Under the Influence of Three Different Materials. BioMed Central Oral Health. 2015; 15:132.
36. Tanimoto K, Sumi K, Yoshioka M, Oki N, Tanne Y, Kato Y, Sugiyama M, Tanne K. Experimental Tooth Movement Into New Bone Area Regenerated by Use of Bone Marrow-Derived Mesenchymal Stem Cells. Cleft Palate-Craniofacial Journal. 2015; 52(4): 386-94
37. Rabie M, Hagg U. Factors Regulating Mandibular Condylar Growth. Hong Kong SAR, China. American Journal of Orthodontics and Dentofacial Orthopedics. 2002; 122(4): 401-409.
38. Moss M. The Functional Matrix Hypothesis Revisited. 4. The Epigenetic Antithesis and the Resolving Synthesis. American Journal of Orthodontics and Dentofacial Orthopedics. 1997; 112 (4).
39. Tanaka E, Sato S. Longitudinal Alteration of the Occlusal Plane and Development of Different Dentoskeletal Frames During Growth. American Journal of Orthodontics and Dento-facial Orthopedics. 2008; 134(5): 410-417.
40. Rabie A, Wong L, Tsai M. Replicating Mesenchymal Cells in the Condyle and the Glenoid Fossa During Mandibular Forward Positioning. American Journal of Orthodontics and Dentofacial Orthopedics. 2003; 123(1): 49-57.
41. Willems N, Langenbach G, Everts V, Zentner A. The Microstructural and Biomechanical Development of the Condylar Bone: a Review. European Journal of Orthodontics. 2013; 36(4): 479-85.
42. Alhadlaq A, Mao J. Tissue-engineered Neogenesis of Human-shaped Mandibular Condyle from Rat Mesenchymal Stem Cells. Journal of Dental Research. 2003; 82(12): 951-956.
43. Kanekawa Mika, Shimizu Noriyoshi. Agerelated Changes on Bone Regeneration in Midpalatal Suture During Maxillary Expansion in the rat. American Journal of Orthodontics and Dentofacial Orthopedics. 1998; 114(6): 646-53.
44. Dai Juan, Rabie M. Gene Therapy to Enhance Condylar Growth Using rAAVVEGF. Angle Orthodontist. 2008; 78(1).
45. Mao J, Wang X, Kopher R. Orthopedic Implications. Angle Orthodontist, 2003; 73(2): 89-94.
46. Mao J. Mechanobiology of Craniofacial Sutures. Journal of Dental Research. 2002; 81(12): 810-6.
47. Hong L, Mao J. Tissue-engineered Rabbit Cranial Suture from Autologous Fibroblasts and BMP2. Journal of Dental Research. 2004; 83(10): 751-6.
48. Shih S, Kyung H, Buschang P. Continuous Forces are More Effective than Intermittent Forces in Expanding Sutures. European Journal of Orthodontics. 2010; 32(4): 371-80.
49. Ekizer A, Yalvac M, Uysal T, Sonmez M, Sahin F. Bone Marrow Mesenchymal Stem Cells Enhance Bone Formation in Orthodontically Expanded Maxillae in Rats. Angle Orthodontist. 2015; 85(6): 1084-5.
50. Osman A, Gnanasegaran N, Govindasamy V, Kathivaloo P, Wen A, Musa S, Abu K. Basal Expression of Growth-Factor-Associated Genes in Periodontal Ligament Stem Cells Reveals Multiple Distinctive Pathways. International Endodontic Journal. 2014; 47(7): 639-51.
51. Athanassiou-Papaefthymiou M, Papagerakis P, Papagerakis S. Isolation and Characterization of Human Adult Epithelial Stem Cells from the Periodontal Ligament. Journal of Dental Research. 2015; 94(11):1591-1600.
2. Li J, Liu D, Zhang F, Wang F, Zhang W, Zhang Z. Human Dental Pulp Stem Cell is a Promising Autologous Seed Cell for Bone Tissue Engineering. Chinese Medical Journal. 2011;124(23):4022-4028
3. Yelick PC, Vacanti J. Bioengineered Teeth from Tooth Bud Cells. The Dental Clinics of North America. 2006; 50(2):191-203.
4. Wise GE, King GJ. Mechanisms of Tooth Eruption and Orthodontic Tooth Movement. Journal of Dental Research. 2008; 87(5):414-34
5. Hiroshi E, Wataru S, Masahiro N, Ikiru A,
Kentaro A. Stem Cells in Dentistry – Part I: Stem Cell Sources: Review. Journal of Prosthodontic Research. 2012;56: 151-65.
6. Hiroshi E, Wataru S, Masahiro N, Ikiru A, Kentaro A. Stem cells in dentistry – Part II: Clinical Applications: Review. Journal of Prosthodontic Research. 2012;16 :229-48.
7. Muñoz W, Trainor P. Neural Crest Cell Evolution: How and When Did a Neural Crest Cell Become a Neural Crest Cell. Current Topics in Developmental Biology. 2015; 111:3-26.
8. Noce, M; Mele, K; Tirino, V; Paino, F. Rosa, A; Naddeo, P; Papagerakis, P; Papaccio, G; Desiderio V. Neural Crest Stem Population in Craniomaxillofacial Development and Tissue Repair. European Cells and Materials. 2014; 28:348-57.
9. Mohanty P, Prasad N, Sahoo N, Kumar G, Mohanty D, Sah S. Reforming Craniofacial Orthodontics Via Stem Cells. Journal of International Society of Preventive and Community Dentistry. 2015; 5(1):13-8.
10. Parada C. Evolución y Desarrollo Facial: Perspectiva Molecular. Universitas Odontológica. 2009; 28(61): 75-85.
11. Hall BK. The Induction of Neural Crestderived Cartilage and Bone by Embryonic Epithelia: an Analysis of the Mode of Action of an Epithelial-mesenchymal Interaction. Journal of Embryology and Experimental Morphology. 1981; 64:305-320
12. Ten R. The Experimental Investigation of Odontogenesis. Journal Developmental Biology. Faculty of Dentistry. 1995; 39:5-11.
13. Kushnerev E, Yates J. Stem Cells in Dentistry – A New Era on the Horizon? Faculty Dental Journal. 2016; 7(2):64-7.
14. Mohammed S, Siar C. Differential Expression of Stem Cell-like Proteins in Normal, Hyperplastic and Dysplastic Oral Epithelium. Journal of Applied Oral Science. 2015; 23(1):79-86.
15. Snider TN, Mishina Y. Cranial Neural Crest Cell Contribution to Craniofacial Formation, Pathology, and Future Directions in Tissue Engineering. National Institutes of Health. 2014; 102(3): 324-332
16. Bunnell B, Flaat M, Gagliardi C, Patel B, Ripoll C. Adipose-derived Stem Cells: Isolation, Expansion and Differentiation. National Institutes of Health. 2008; 45(2): 115-20.
17. Yao S, Pan F, Prpic V, Wise GE. Differentiation of Stem Cells in the Dental Follicle. Journal of Dental Research. 2008; 87(8):767-71.
18. Yanding Z, YiPing C. Bioengineering of a Human Whole Tooth: Progress and Challenge. Cell Regeneration. 2014;3-8.
19. Rocha R. Expanding Therapeutic Boundaries: Stem Cells and Tissue Engineering. Dental Press Journal of Orthodontics. 2011; 16(5):17-9.
20. Mérida I. Bioingeniería y su Aplicación en la Ortodoncia. Revista Latinoamericana de Ortodoncia y Odonotopediatría. 2011.
21. Jasso G, Adalpe B. Bioingeniería Dental ¿El Futuro de la Terapia en Odontología? Revista Asociación Dental Mexicana. 2011; 68(4): 169-74.
22. Hynes K, Menichanin D, Bright R, Ivanovski S, Hutmacher D, Gronthos S, Bartold P. Induced Pluripotent Stem Cells: A New Frontier for Stem Cells in Dentistry. Journal of Dental Research. 2015; 94(11): 1508-15.
23. Margarita D, Diekwisch T, Fincham A, Lau E, McDougall M, Moradian J, Simmer J, Snead M, Slavkin H. Control of Ameloblast Differentiation. Special Review. The International Journal Developmental Biology. 1995; 39(1): 69-72.
24. Zhao H, Chai Y. Stem Cells in Teeth and Craniofacial Bones. Journal of Dental Research. 2015; 94(11): 1495-501.
25. Atalayin C, Tezel H, Dagci T, Karabay Y, Oktem G. Medium Modification with Bone Morphogenetic Protein 2 Addition for Odontogenic Differentiation. Brazilian Oral Research. 2016; 30(1):1-9
26. Carrillo N, García D, Otero L. Aislamiento y Capacidad de Osteodiferenciación de las Células Madre Provenientes del Ligamento Periodontal y Pulpa Dental. Revista CES Odontología. 2015; 28(2): 20-34.
27. Arechaga J. The Tooth as a Model in Organogenesis. An Interview with Professor Harold C. Slavkin. The International Journal of Developmental Biology. 1995; 39(1):13-23.
28. Dabas A, Dabas N, Prabhakar M, Sidhu M. Regenerative Dentistry: A Journey From Stem Cell To A Bio-Tooth. Indian Journal of Dental Sciences. 2013; 5(1).
29. Volponi A, Gentleman E, Fatscher R, Pang Y, Gentleman M, Sharpe P. Composition of Mineral Produced by Dental Mesenchymal Stem Cells. Journal of Dental Research. 2015; 94(11) 1568-74.
30. Volponi A, Kawasaki M, Sharpe P. Adult Human Gingival Epithelial Cells as a Source for Whole-tooth Bioengineering. Research Reports. International & American Associations for Dental Research. 2013; 92(4):329-34.
31. Gao Z, Hu L, Liu G. Bio-Root and Implant-Based Restoration as a Tooth Replacement Alternative. Journal of Dental Research. 2016; 95(6) 642-9.
32. Boke F, Gazioglu C, Akkaya S, Akkaya M. Relationship Between Orthodontic Treatment and Gingival Health: A Restrospective Study. European Journal of Dentistry. 2014; 8(3): 373-80.
33. Alfuriji S, Alhazmi N, Alhamkan N, Ehaideb A, Alruwaithi M, Alkatheeri N, Geevarghese A. The Effect of Orthodontic Therapy on Periodontal Health: A Review of the Literature. International Journal of Dentistry. 2014; 139(4): 413-22.
34. Wise G, Frazier S, Souza R. Cellular, Molecular, and Genetic Determinants of Tooth Eruption. Critical Reviews in Oral Biology & Medicine. 2002; 13(4): 323-34.
35. Ajlan S, Ashri N, Aldahmash A, Alnbaheen M. Osteogenic Differentiation of Dental Pulp Stem Cells Under the Influence of Three Different Materials. BioMed Central Oral Health. 2015; 15:132.
36. Tanimoto K, Sumi K, Yoshioka M, Oki N, Tanne Y, Kato Y, Sugiyama M, Tanne K. Experimental Tooth Movement Into New Bone Area Regenerated by Use of Bone Marrow-Derived Mesenchymal Stem Cells. Cleft Palate-Craniofacial Journal. 2015; 52(4): 386-94
37. Rabie M, Hagg U. Factors Regulating Mandibular Condylar Growth. Hong Kong SAR, China. American Journal of Orthodontics and Dentofacial Orthopedics. 2002; 122(4): 401-409.
38. Moss M. The Functional Matrix Hypothesis Revisited. 4. The Epigenetic Antithesis and the Resolving Synthesis. American Journal of Orthodontics and Dentofacial Orthopedics. 1997; 112 (4).
39. Tanaka E, Sato S. Longitudinal Alteration of the Occlusal Plane and Development of Different Dentoskeletal Frames During Growth. American Journal of Orthodontics and Dento-facial Orthopedics. 2008; 134(5): 410-417.
40. Rabie A, Wong L, Tsai M. Replicating Mesenchymal Cells in the Condyle and the Glenoid Fossa During Mandibular Forward Positioning. American Journal of Orthodontics and Dentofacial Orthopedics. 2003; 123(1): 49-57.
41. Willems N, Langenbach G, Everts V, Zentner A. The Microstructural and Biomechanical Development of the Condylar Bone: a Review. European Journal of Orthodontics. 2013; 36(4): 479-85.
42. Alhadlaq A, Mao J. Tissue-engineered Neogenesis of Human-shaped Mandibular Condyle from Rat Mesenchymal Stem Cells. Journal of Dental Research. 2003; 82(12): 951-956.
43. Kanekawa Mika, Shimizu Noriyoshi. Agerelated Changes on Bone Regeneration in Midpalatal Suture During Maxillary Expansion in the rat. American Journal of Orthodontics and Dentofacial Orthopedics. 1998; 114(6): 646-53.
44. Dai Juan, Rabie M. Gene Therapy to Enhance Condylar Growth Using rAAVVEGF. Angle Orthodontist. 2008; 78(1).
45. Mao J, Wang X, Kopher R. Orthopedic Implications. Angle Orthodontist, 2003; 73(2): 89-94.
46. Mao J. Mechanobiology of Craniofacial Sutures. Journal of Dental Research. 2002; 81(12): 810-6.
47. Hong L, Mao J. Tissue-engineered Rabbit Cranial Suture from Autologous Fibroblasts and BMP2. Journal of Dental Research. 2004; 83(10): 751-6.
48. Shih S, Kyung H, Buschang P. Continuous Forces are More Effective than Intermittent Forces in Expanding Sutures. European Journal of Orthodontics. 2010; 32(4): 371-80.
49. Ekizer A, Yalvac M, Uysal T, Sonmez M, Sahin F. Bone Marrow Mesenchymal Stem Cells Enhance Bone Formation in Orthodontically Expanded Maxillae in Rats. Angle Orthodontist. 2015; 85(6): 1084-5.
50. Osman A, Gnanasegaran N, Govindasamy V, Kathivaloo P, Wen A, Musa S, Abu K. Basal Expression of Growth-Factor-Associated Genes in Periodontal Ligament Stem Cells Reveals Multiple Distinctive Pathways. International Endodontic Journal. 2014; 47(7): 639-51.
51. Athanassiou-Papaefthymiou M, Papagerakis P, Papagerakis S. Isolation and Characterization of Human Adult Epithelial Stem Cells from the Periodontal Ligament. Journal of Dental Research. 2015; 94(11):1591-1600.
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