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Introduction: Antimicrobial nanoparticles such as graphene, silver, chitosan, poly (lactic) co glycolic acid, bioactive glass, mesoporous calcium silicate, copper, have generated promising results in various applications in endodontics in the incorporation of nanoparticles in sealants, irrigants and intraductal medications.
Objective: identify the mechanisms of action of the different nanoparticles in the disinfection of root canals.
Materials and methods: an exhaustive bibliographic search of original studies was carried out in the databases Medline (Pubmed), Scielo, Lilacs, Medline (Ovid), Web of science, Scopus, Embase, Google academic, choosing in vitro studies published from From 2010 to 2021, the QRayyan tool was used to select the definitive articles, excluding sources of information from animal studies, studies that did not use nanoparticles during the disinfection protocol, literature reviews and/or meta-analysis.
Results: A total of 1,567 references were identified and 17 definitive documents were selected for use in this review, each study demonstrated a clear antibacterial effect and a significant antimicrobial reduction in root canal disinfection.
Conclusions: the use of nanoparticles in endodontics is a promising option in root canal therapy, all nanoparticles reviewed in this research demonstrated antimicrobial effectiveness in root canals, further in-vivo studies are recommended to determine adverse effects, cytotoxicity and efficacy in different types of microorganisms.

Gustavo Adolfo Tovar Rangel , Universidad del Valle, Facultad de Salud, Escuela de Odontología, Departamento de Endodoncia, Cali, Colombia.

Universidad del Valle, Facultad de Salud, Escuela de Odontología, Departamento de Endodoncia, Cali, Colombia.

Fanny Mildred González Sáenz , Universidad del Valle, Facultad de Salud, Escuela de Odontología, Departamento de Endodoncia, Cali, Colombia.

Universidad del Valle, Facultad de Salud, Escuela de Odontología, Departamento de Endodoncia, Cali, Colombia.

Ingrid Ximena Zamora Córdoba , Universidad del Valle, Facultad de Salud, Escuela de Odontología, Departamento de Endodoncia, Cali, Colombia.

Universidad del Valle, Facultad de Salud, Escuela de Odontología, Departamento de Endodoncia, Cali, Colombia.

Lina María García Zapata , Universidad del Valle, Facultad de Salud, Escuela de Odontología, Departamento de Endodoncia, Cali, Colombia.

Universidad del Valle, Facultad de Salud, Escuela de Odontología, Departamento de Endodoncia, Cali, Colombia.

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