Oral Blue Nevus two case reports and literature review.
Article Sidebar
Main Article Content
Case Description We report two cases of oral Blue Nevus. The first case is a 32 years old female patient with a brown-blue lesion on hard palate, with no clinical symptoms that has always been present but that recently has been growing. The case is 36 years old male patient with a brown macule on hard palate.
Clinical Findings On case report 1, oral examinations revealed an irregular brown-blue macule, measuring 13 x 6mm on hard palate. On case report 2, oral examination showed an oval brownish macule also located on hard palate.
Treatment and Outcome: Excisional biopsy was performed in both cases and histopathology analyses revealed diagnosis of Blue Nevus.
Clinical Relevance Diagnosis of pigmented lesions of the oral cavity can be challenging once there are a variety of causes such as racial pigmentation, systemic diseases, use of medication, metal tattooing melanocytic nevus, melanoacanthoma, and melanoma. The correct diagnosys is important to conduct the best management of these lesions, especially the ones with malignancy potential.
Murali R, McCarthy SW, Scolyer RA. Blue nevi and related lesions: a review highlighting atypical and newly described variants, distinguishing features and diagnostic pitfalls. Adv Anat Pathol. 2009;16(6):365-82. Doi: https://doi.org/10.1097/PAP.0b013e3181bb6b53
Santos Tde S, Frota R, Martins-Filho PR, Cavalcante JR, Raimundo Rde C, Andrade ES. Extensive intraoral blue nevus--case report. An Bras Dermatol. 2011;86(4 Suppl 1):S61-5. Doi: https://doi.org/10.1590/S0365-05962011000700015
Pinto A, Raghavendra S, Lee R, Derossi S, Alawi F. Epithelioid blue nevus of the oral mucosa: a rare histologic variant. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2003;96(4):429-36. Doi: https://doi.org/10.1016/S1079-2104(03)00319-6
Oliveira AHK, Shiraishi A, Kadunc BV, Sotero PC, Stelini RF, Mendes C. Blue nevus with satellitosis: case report and literature review. An Bras Dermatol. 2017;92(5 Suppl 1):30-3. Doi: https://doi.org/10.1590/abd1806-4841.20175267
Eisen D. Disorders of pigmentation in the oral cavity. Clin Dermatol. 2000;18(5):579-87. Doi: https://doi.org/10.1016/S0738-081X(00)00148-6
Lenane P, Powell FC. Oral pigmentation. J Eur Acad Dermatol Venereol. 2000;14(6):448-65. Doi: https://doi.org/10.1046/j.1468-3083.2000.00143.x
Phadke PA, Zembowicz A. Blue nevi and related tumors. Clin Lab Med. 2011;31(2):345-58. Doi: https://doi.org/10.1016/j.cll.2011.03.011
Gondak RO, da Silva-Jorge R, Jorge J, Lopes MA, Vargas PA. Oral pigmented lesions: Clinicopathologic features and review of the literature. Med Oral Patol Oral Cir Bucal. 2012;17(6):e919-24. Doi: https://doi.org/10.4317/medoral.17679
Shumway BS, Rawal YB, Allen CM, Kalmar JR, Magro CM. Oral atypical cellular blue nevus: an infiltrative melanocytic proliferation. Head Neck Pathol. 2013;7(2):171-7. Doi: https://doi.org/10.1007/s12105-012-0386-z
Ensslin CJ, Hibler BP, Lee EH, Nehal KS, Busam KJ, Rossi AM. Atypical Melanocytic Proliferations: A Review of the Literature. Dermatol Surg. 2018;44(2):159-174. Doi: https://doi.org/10.1097/DSS.0000000000001367
Buchner A, Merrell PW, Carpenter WM. Relative frequency of solitary melanocytic lesions of the oral mucosa. J Oral Pathol Med. 2004;33(9):550-7. Doi: https://doi.org/10.1111/j.1600-0714.2004.00238.x
Tieche M. Uber benigne Melanome (Cbromatophorome) der Ham-"blaue Naevi,". Virchow's Arch. Pathol. Anat.; 1906. p. 212-29. Doi: https://doi.org/10.1515/9783112385005-009
Ojha J, Akers JL, Akers JO, Hassanein AM, Islam NM, Cohen DM, et al. Intraoral cellular blue nevus: report of a unique histopathologic entity and review of the literature. Cutis. 2007;80(3):189-92.
Kauzman A, Pavone M, Blanas N, Bradley G. Pigmented lesions of the oral cavity: review, differential diagnosis, and case presentations. J Can Dent Assoc. 2004;70(10):682-3.
Kittler H. Evolution of the Clinical, Dermoscopic and Pathologic Diagnosis of Melanoma. Dermatol Pract Concept. 2021;1(11):e2021163S. Doi: https://doi.org/10.5826/dpc.11S1a163S
Porter SR, Scully C. Adverse drug reactions in the mouth. Clin Dermatol. 2000;18(5):525-32. Doi: https://doi.org/10.1016/S0738-081X(00)00143-7
de Andrade BA, Fonseca FP, Pires FR, Mesquita AT, Falci SG, Dos Santos Silva AR, et al. Hard palate hyperpigmentation secondary to chronic chloroquine therapy: report of five cases. J Cutan Pathol. 2013;40(9):833-8. Doi: https://doi.org/10.1111/cup.12182
Buchner A, Hansen LS. Pigmented nevi of the oral mucosa: a clinicopathologic study of 36 new cases and review of 155 cases from the literature. Part I: A clinicopathologic study of 36 new cases. Oral Surg Oral Med Oral Pathol. 1987;63(5):566-72. Doi: https://doi.org/10.1016/0030-4220(87)90229-5
Gray-Schopfer VC, Cheong SC, Chong H, Chow J, Moss T, Abdel-Malek ZA, et al. Cellular senescence in naevi and immortalisation in melanoma: a role for p16? Br J Cancer. 2006;95(4):496-505. Doi: https://doi.org/10.1038/sj.bjc.6603283
Rapini RP. Oral melanoma: diagnosis and treatment. Semin Cutan Med Surg. 1997;16(4):320-2. Doi: https://doi.org/10.1016/S1085-5629(97)80023-5
Brasil Cda M, Ribeiro CM, Fonseca DD, Gueiros LA, Leao JC. Chloroquine-induced hyperpigmentation of the hard palate. Gen Dent. 2012;60(2):e74-8.
Lerman MA, Karimbux N, Guze KA, Woo SB. Pigmentation of the hard palate. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2009;107(1):8-12. Doi: https://doi.org/10.1016/j.tripleo.2008.07.022
Amerigo-Gongora M, Machuca-Portillo G, Torres-Lagares D, Lesclous P, Amerigo-Navarro J, Gonzalez-Campora R. Clinicopathological and immunohistochemical analysis of oral melanocytic nevi and review of the literature. J Stomatol Oral Maxillofac Surg. 2017;118(3):151-5. Doi: https://doi.org/10.1016/j.jormas.2017.03.003
Barker GR, Sloan P. An intraoral combined blue naevus. Br J Oral Maxillofac Surg. 1988;26(2):165-8. Doi: https://doi.org/10.1016/0266-4356(88)90014-9
Fistarol SK, Itin PH. Plaque-type blue nevus of the oral cavity. Dermatology. 2005;211(3):224-33. Doi: https://doi.org/10.1159/000087016
Pennacchiotti G, Oviedo C, Ortega-Pinto A. Solitary pigmented lesions in oral mucosa in Latin American children: A case series. Pediatr Dermatol. 2018;35(3):374-7. Doi: https://doi.org/10.1111/pde.13465
Kaugars GE, Heise AP, Riley WT, Abbey LM, Svirsky JA. Oral melanotic macules. A review of 353 cases. Oral Surg Oral Med Oral Pathol. 1993;76(1):59-61. Doi: https://doi.org/10.1016/0030-4220(93)90295-F
Dorsey CS, Montgomery H. Blue nevus and its distinction from Mongolian spot and the nevus of Ota. J Invest Dermatol. 1954;22(3):225-36. Doi: https://doi.org/10.1038/jid.1954.28
Donnell CC, Walton RL, Carrozzo M. The blue palate-A case series of imatinib-related oral pigmentation and literature review. Oral Surg Oral Med Oral Pathol Oral Radiol. 2021;131(1):49-61. Doi: https://doi.org/10.1016/j.oooo.2020.10.015
- Evandro Silveira de Oliveira, Olga Dumont Flecha , Pedro Henrique Scheidt Figueiredo , Cássio Roberto Rocha dos Santos, Vanessa Gomes Brandão Rodrigues, Frederico Lopes Alves, Emilio Henrique Barroso Maciel , Larissa Doalla de Almeida e Silva, Dhelfeson Willya Douglas-de-Oliveira, Jéssica Vidal da Silva, Patricia Furtado Gonçalves, Relationship between prosthetic treatment, self-esteem and quality of life in elderly patients undergoing hemodialysis , Revista Estomatología: Vol. 29 No. 2 (2021)
- Luana Moreira, Mariana Pontes, Egina Brum, Larissa Silva, Dhelfeson Douglas de Oliveira, Amanda Figueiredo, Patricia Gonçalves, Olga Flecha, Evandro Oliveira, The effectiveness of apple, sugar-free chewing gum and Rolly Brush® in the reduction of plaque index: crossover randomized clinical trial , Revista Estomatología: Vol. 29 No. 1 (2021)
- Lara Oliveira Freitas, Priscila Seixas Mourão, Moisés Willian Aparecido Gonçalves, Maria Letícia Ramos-Jorge, Ana Terezinha Marques Mesquita , Congenital atresia of the submandibular gland duct: report of two clinical cases with spontaneous regression and literature review , Revista Estomatología: Vol. 30 No. 1 (2022)
- Moisés Willian Aparecido Gonçalves, Marina Rocha Fonseca Souza, Larissa Doalla de Almeida e Silva, Cássio Roberto Rocha dos Santos, João Luiz de Miranda, Jorge Esquiche León, Ana Terezinha Marques Mesquita , Nodular fasciitis on the zygomatic region: immunohistochemical analysis and literature review , Revista Estomatología: Vol. 30 No. 1 (2022)
Accepted 2021-12-20
Published 2021-09-15
This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.
Los autores/as conservan los derechos de autor y ceden a la revista el derecho de la primera publicación, con el trabajo registrado con la licencia de atribución de Creative Commons, que permite a terceros utilizar lo publicado siempre que mencionen la autoría del trabajo y a la primera publicación en esta revista.