Trigeminal Neuralgia: Anticonvulsants and Antidepressants
Article Sidebar
Main Article Content
Orofacial neuropathic pain happens due to somatosensory nervous system injury or disease in the orofacial region. Multiple types of orofacial neuropathic pain have been identified, including nonodontogenic neuropathic orofacial pain, postherpetic neuralgia, atypical odontalgia, glossopharyngeal neuralgia and trigeminal neuralgia. Currently, pharmacological intervention is well known as the foundation for managing neuropathic pain. Drugs from different classifications, including anticonvulsants, antidepressants, opioids, and nonsteroidal anti-inflammatory drugs, are generally used to treat these events. However, these drugs are not yet broadly accepted for these treatments. This review will explore recent clinical findings and fragments of evidence regarding anticonvulsants and antidepressants in the management of trigeminal neuralgia.
Crandall JA. An Introduction to Orofacial Pain. Dent Clin North Am. 2018;62(4):511-23. DOI: https://doi.org/10.1016/j.cden.2018.05.001
Balasubramaniam R, Klasser GD. Orofacial pain syndromes: evaluation and management. Med Clin North Am. 2014;98(6):1385-405. DOI: https://doi.org/10.1016/j.mcna.2014.08.007
Ghurye S, McMillan R. Orofacial pain - an update on diagnosis and management. Br Dent J. 2017;223(9):639-47. DOI: https://doi.org/10.1038/sj.bdj.2017.879
Gambeta E, Chichorro JG, Zamponi GW. Trigeminal neuralgia: An overview from pathophysiology to pharmacological treatments. Mol Pain. 2020;16:1744806920901890. DOI: https://doi.org/10.1177/1744806920901890
Jessri M, Sultan AS, Tavares T, Schug S. Central mechanisms of pain in orofacial pain patients: Implications for management. J Oral Pathol Med. 2020;49(6):476-83. DOI: https://doi.org/10.1111/jop.13062
Jones MR, Urits I, Ehrhardt KP, Cefalu JN, Kendrick JB, Park DJ, et al. A comprehensive review of trigeminal neuralgia. Current pain and headache reports. 2019;23(10):1-7. DOI: https://doi.org/10.1007/s11916-019-0810-0
Prasad S, Galetta S. Trigeminal Neuralgia: Historical Notes and Current Concepts. The Neurologist (Baltimore, Md). 2009;15(2):87-94. DOI: https://doi.org/10.1097/NRL.0b013e3181775ac3
Reddy GDMDP, Viswanathan AMD. Trigeminal and Glossopharyngeal Neuralgia. Neurologic clinics. 2014;32(2):539-52. DOI: https://doi.org/10.1016/j.ncl.2013.11.008
Rozen TD. Trigeminal neuralgia andglossopharyngeal neuralgia. Neurologic clinics. 2004;22(1):185-206. DOI: https://doi.org/10.1016/S0733-8619(03)00094-X
Cruccu G, Finnerup NB, Jensen TS, Scholz J, Sindou M, Svensson P, et al. Trigeminal neuralgia: new classification and diagnostic grading for practice and research. Neurology. 2016;87(2):220-8. DOI: https://doi.org/10.1212/WNL.0000000000002840
Al-Quliti KW. Update on neuropathic pain treatment for trigeminal neuralgia. The pharmacological and surgical options. Neurosciences (Riyadh, Saudi Arabia). 2015;20(2):107-14. DOI: https://doi.org/10.17712/nsj.2015.2.20140501
Bendtsen L, Zakrzewska J, Abbott Ja, Braschinsky M, Di Stefano G, Donnet A, et al. European Academy of Neurology guideline on trigeminal neuralgia. European journal of neurology. 2019;26(6):831-49. DOI: https://doi.org/10.1111/ene.13950
Keppel Hesselink JM, Schatman ME. Phenytoin and carbamazepine in trigeminal neuralgia: marketing-based versus evidence-based treatment. Journal of pain research. 2017;10:1663-6. DOI: https://doi.org/10.2147/JPR.S141896
Attal N, Cruccu G, Baron R, Haanpää M, Hansson P, Jensen TS, et al. EFNS guidelines on the pharmacological treatment of neuropathic pain: 2010 revision. European journal of neurology. 2010;17(9):1113-e88. DOI: https://doi.org/10.1111/j.1468-1331.2010.02999.x
Bazzari FH, Bazzari AH. Orofacial neuropathic pain : a pharmacological approach. SA Pharmaceutical Journal. 2019;86(4):23-8.
Clark G. Evidence-Based Pharmacologic Approaches for Chronic Orofacial Pain. J Calif Dent Assoc. 2015;43(11):643-54. DOI: https://doi.org/10.1080/19424396.2015.12222915
Dexter M, Aggarwal A. Medical, pharmacological and neurosurgical perspectives on trigeminal neuralgia. Australian Endodontic Journal. 2018;44:136-47. DOI: https://doi.org/10.1111/aej.12255
Maarbjerg S, Benoliel R. The changing face of trigeminal neuralgia—A narrative review. Headache. 2021;61(6):817-37. DOI: https://doi.org/10.1111/head.14144
Phillip Siddall RD. Advance Studies in Orofacial Pain: Module 2: Neuropathic Orofacial Pain. University of Sydney | All rights reserved. 2019;V1.
Vargas-Espinosa ML, Sanmartí-García G, Vázquez-Delgado E, Gay-Escoda C. Antiepileptic drugs for the treatment of neuropathic pain: a systematic review. Medicina Oral, Patología Oral y Cirugía Bucal. 2012;17(5):e786. DOI: https://doi.org/10.4317/medoral.18001
Qin Z, Xie S, Mao Z, Liu Y, Wu J, Furukawa TA, et al. Comparative efficacy and acceptability of antiepileptic drugs for classical trigeminal neuralgia: a Bayesian network meta-analysis protocol. BMJ open. 2018;8(1):e017392-e. DOI: https://doi.org/10.1136/bmjopen-2017-017392
Zilliox LA. Neuropathic pain. CONTINUUM: Lifelong Learning in Neurology. 2017;23(2):512-32. DOI: https://doi.org/10.1212/CON.0000000000000462
Benoliel R, Eliav E. Neuropathic orofacial pain. Alpha Omegan. 2012;105(3-4):66-74.
Zakrzewska JM, Akram H. Neurosurgical interventions for the treatment of classical trigeminal neuralgia. Cochrane Database of Systematic Reviews. 2011(9). DOI: https://doi.org/10.1002/14651858.CD007312.pub2
Devor M, Amir R, Rappaport ZH. Pathophysiology of trigeminal neuralgia: the ignition hypothesis. The Clinical journal of pain. 2002;18(1):4-13. DOI: https://doi.org/10.1097/00002508-200201000-00002
Liu M, Zhong J, Xia L, Dou N, Li S. The expression of voltage-gated sodium channels in trigeminal nerve following chronic constriction injury in rats. International Journal of Neuroscience. 2019;129(10):955-62. DOI: https://doi.org/10.1080/00207454.2019.1595616
O'Connor ABMDMPH, Dworkin RHP. Treatment of Neuropathic Pain: An Overview of Recent Guidelines. The American journal of medicine. 2009;122(10):S22-S32. DOI: https://doi.org/10.1016/j.amjmed.2009.04.007
Romero-Reyes M, Uyanik JM. Orofacial pain management: current perspectives. Journal of Pain Research. 2014;7:99-115. DOI: https://doi.org/10.2147/JPR.S37593
Tricyclic antidepressants (TCAs) are first-line drugs for the treatment of neuropathic pain, but their mechanisms of action in this context are unclear. Nature reviews Neurology. 2009;5(5):238.
An update on the drug treatment of neuropathic pain. Part 1: antidepressants. Drug and therapeutics bulletin. 2012;50(10):114-93. DOI: https://doi.org/10.1136/dtb.2012.10.0133
Renton T. Chronic orofacial pain. Oral diseases. 2017;23(5):566-71. DOI: https://doi.org/10.1111/odi.12540
Di Stefano G, Truini A, Cruccu G. Current and Innovative Pharmacological Options to Treat Typical and Atypical Trigeminal Neuralgia. Drugs (New York, NY). 2018;78(14):1433-42. DOI: https://doi.org/10.1007/s40265-018-0964-9
An update on the drug treatment of neuropathic pain. Part 2: antiepileptics and other drugs. Drug and Therapeutics Bulletin. 2012;50(11):126. DOI: https://doi.org/10.1136/dtb.2012.11.0139
Zakrzewska JM. Medical management of trigeminal neuropathic pains. Expert opinion on pharmacotherapy. 2010;11(8):1239-54. DOI: https://doi.org/10.1517/14656561003767449
Sansone RA, Sansone LA. Pain, pain, go away: antidepressants and pain management. Psychiatry (Edgmont). 2008;5(12):16-9.
Cardoso FC, Schmit M, Kuiper MJ, Lewis RJ, Tuck KL, Duggan PJ. Inhibition of N-type calcium ion channels by tricyclic antidepressants - experimental and theoretical justification for their use for neuropathic pain. RSC Med Chem. 2022;13(2):183-95. DOI: https://doi.org/10.1039/D1MD00331C
Schimmel M, Aarab G, Baad-Hansen L, Lobbezoo F, Svensson P. A conceptual model of oro-facial health with an emphasis on function. J Oral Rehabil. 2021;48(11):1283-94. DOI: https://doi.org/10.1111/joor.13250
Zakrzewska JM. Multi-dimensionality of chronic pain of the oral cavity and face. J Headache Pain. 2013;14(1):37-. DOI: https://doi.org/10.1186/1129-2377-14-37
Halpern L, Willis P. Orofacial Pain: Pharmacologic Paradigms for Therapeutic Intervention. Dent Clin North Am. 2016;60(2):381-405. DOI: https://doi.org/10.1016/j.cden.2015.11.011
Lambru G, Zakrzewska J, Matharu M. Trigeminal neuralgia: a practical guide. Pract Neurol. 2021;21(5):392-402. DOI: https://doi.org/10.1136/practneurol-2020-002782
Edwards RR, Dworkin RH, Sullivan MD, Turk DC, Wasan AD. The Role of Psychosocial Processes in the Development and Maintenance of Chronic Pain. J Pain. 2016;17(9 Suppl):T70-T92. DOI: https://doi.org/10.1016/j.jpain.2016.01.001
Roditi D, Robinson ME. The role of psychological interventions in the management of patients with chronic pain. Psychol Res Behav Manag. 2011;4:41-9. DOI: https://doi.org/10.2147/PRBM.S15375
- Andres Felipe Aguirre Osorio, Systemic Factors in Dental Implant Therapy , Revista Estomatología: Vol. 32 No. 2 (2024)
Accepted 2023-10-06
Published 2023-10-06
This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.
Los autores/as conservan los derechos de autor y ceden a la revista el derecho de la primera publicación, con el trabajo registrado con la licencia de atribución de Creative Commons, que permite a terceros utilizar lo publicado siempre que mencionen la autoría del trabajo y a la primera publicación en esta revista.