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Background: After more than 15 years of the first report of osteonecrosis associated with bisphosphonate (BP), still cases related to BP and other medications continue to be reported and there is an alert about the increase in the number of prescriptions. The need for both patients and students and health professionals to be familiar with medications, pathology, prevention and treatment measures has been highlighted.

Aim: To characterize patients with osteonecrosis in the maxilla associated to bisphosphonate (BRONJ), from Cali, Colombia.

Materials and Methods: A structured survey was conducted of 32 maxillofacial surgeons from the city of Cali, Colombia, where different topics related to affected patients and the development of the pathology such as age and gender of patients, type of medication, time of study were asked. administration, exposed bone, etc.

Results: Thirty-two maxillofacial surgeons answered the survey with a total of 8 cases, it was found that 6 corresponded to women and 2 to men and the age was over 44 years; 4 of the treatments were oral prescription and 4 intravenous; the majority of cases were presented in the jaw (88%) and 6 cases (75%) presented bone exposure.

Conclusions: Osteonecrosis associated with bisphosphonates is a situation that still occurs and could increase its incidence due to the increase in the number of prescriptions for osteoporosis medications, it is necessary that the patient community and health staff know More about this situation.

León Arcila, M. E., & Valencia, C. (2020). Osteonecrosis of the jaw associated to biphosponates in Cali-Colombia. Revista Estomatología, 27(2), 11–18.

Shibahara T, Morikawa T, Yago K, Kishimoto H, Imai Y, Kurita K. National Survey on Bisphosphonate-Related Osteonecrosis of the Jaws in Japan. J Oral Maxillofac Surg [Internet]. 2018;76(10):2105–12. Available from:

Gómez, J ; Sanders, K; Laguna, F; Montaño C. Osteonecrosis asociada a bifosfonatos: su influencia en la práctica odontológica. Rev ADM. 2009;LXV(4):36:44.

Guo Z, Cui W, Que L, Li C, Tang X, Liu J. Pharmacogenetics of medication-related osteonecrosis of the jaw: a systematic review and meta-analysis. Int J Oral Maxillofac Surg. 2019;49(3):298–309.

George EL, Lin YL, Saunders MM. Bisphosphonate-related osteonecrosis of the jaw: a mechanobiology perspective. Bone Reports [Internet]. 2018;8:104–9. Available from:

Cariolatto F, Carelli J, Taís M, Pietrobon R, Rodrigues C, Bonilauri A. Recommendations for the Prevention of Bisphosphonate-Related Osteonecrosis of the Jaw: A Systematic Review. J Evid Based Dent Pract [Internet]. 2018;18(2):142–52. Available from:

Balkhi B, Seoane-Vazquez E, Rodriguez-Monguio R. Changes in the utilization of osteoporosis drugs after the 2010 FDA bisphosphonate drug safety communication. Saudi Pharm J [Internet]. 2018;26(2):238–43. Available from:

Wotton CJ, Green J, Brown A, Armstrong MEG, Floud S, Beral V, et al. Use of oral bisphosphonates and risk of hospital admission with osteonecrosis of the jaw: Large prospective cohort study in UK women. Bone [Internet]. 2019;124(April):69–74. Available from:

Wang Q, Liu J, Qi S, Liao X, Liu D, Pan J. Clinical analysis of medication related osteonecrosis of the jaws: A growing severe complication in China. J Dent Sci [Internet]. 2018;13(3):190–7. Available from:

Duarte NT, Rech B de O, Martins IG, Franco JB, Ortega KL. Can children be affected by bisphosphonate-related osteonecrosis of the jaw? A systematic review. Int J Oral Maxillofac Surg. 2019;49(2):83–191.

Ristow O, Rückschloß T, Müller M, Berger M, Kargus S, Pautke C, et al. Is the conservative non-surgical management of medication-related osteonecrosis of the jaw an appropriate treatment option for early stages? A long-term single-center cohort study. J Cranio-Maxillofacial Surg [Internet]. 2019;47(3):491–9. Available from:

Matsuda S, Yoshimura H, Sano K. Risk factors and treatments for medication-related osteonecrosis of the jaw: A 10-year single-institution experience. J Oral Maxillofac Surgery, Med Pathol [Internet]. 2018;30(1):10–6. Available from:

Kuroshima S, Sasaki M, Sawase T. Medication-related osteonecrosis of the jaw: A literature review. J Oral Biosci [Internet]. 2019;61(2):99–104. Available from:

Hallmer F, Andersson G, Götrick B, Warfvinge G, Anderud J, Bjørnland T. Prevalence, initiating factor, and treatment outcome of medication-related osteonecrosis of the jaw—a 4-year prospective study. Oral Surg Oral Med Oral Pathol Oral Radiol. 2018;126(6):477–85.

Sammut S, Malden N, Lopes V, Ralston S. Epidemiological study of alendronate-related osteonecrosis of the jaw in the southeast of Scotland. Br J Oral Maxillofac Surg [Internet]. 2016;54(5):501–5. Available from:

Yuan A, Munz A, Reinert S, Hoefert S. Gingival fibroblasts and medication-related osteonecrosis of the jaw: Results by real-time and wound healing in vitro assays. J Cranio-Maxillofacial Surg [Internet]. 2019;47(9):1464–74. Available from:

Lemound J, Muecke T, Zeller AN, Lichtenstein J, Eckardt A, Gellrich NC. Nasolabial Flap Improves Healing in Medication-Related Osteonecrosis of the Jaw. J Oral Maxillofac Surg. 2018;76(4):877–85.

Ribeiro GH, Chrun ES, Dutra KL, Daniel FI, Grando LJ. Osteonecrosis of the jaws: a review and update in etiology and treatment. Braz J Otorhinolaryngol [Internet]. 2018;84(1):102–8. Available from:

Cortés-Motta MC, Fernández-Grisales R. Osteonecrosis de los maxilares: fisiopatología, diagnóstico y tratamiento. CES Odontol. 2016;29(2):65–77.

Pichardo SEC, Kuijpers SCC, van Merkesteyn JPR. Bisphosphonate-related osteonecrosis of the jaws: Cohort study of surgical treatment results in seventy-four stage II/III patients. J Cranio-Maxillofacial Surg [Internet]. 2016;44(9):1216–20. Available from:

Pichardo S, Broek F, Van Merkesteyn JP. Treatment of pathologic fractures of the mandible in stage III medication-related osteonecrosis of the jaw—an observational study. J Cranio-Maxillofacial Surg [Internet]. 2018;46(8):1241–1246. Available from:

Topaloglu G, Koseoglu OT, Karaca C, Kosemehmetoglu K. The effect of chronic dental inflammation on development of Stage 0 medication-related osteonecrosis of the jaw. J Cranio-Maxillofacial Surg [Internet]. 2017;45(8):1158–1164. Available from:

Song M, Alshaikh A, Kim T, Kim S, Dang M, Mehrazarin S, et al. Preexisting Periapical Inflammatory Condition Exacerbates Tooth Extraction–induced Bisphosphonate-related Osteonecrosis of the Jaw Lesions in Mice. J Endod [Internet]. 2016;42(11):1641–1646. Available from:

Kuroshima S, Sasaki M, Nakajima K, Tamaki S, Hayano H, Sawase T. Prevalence of bisphosphonate-related osteonecrosis of the jaw-like lesions is increased in a chemotherapeutic dose-dependent manner in mice. Bone [Internet]. 2018;112:177–86. Available from:

Zandi M, Dehghan A, Janbaz P, Malekzadeh H, Amini P. The starting point for bisphosphonate-related osteonecrosis of the jaw: Alveolar bone or oral mucosa? A randomized, controlled experimental study. J Cranio-Maxillofacial Surg [Internet]. 2017;45(1):157–161. Available from:

Signi C. Bisphosphonate suspension and osteonecrosis of the jaw. Dent Abstr. 2018;63(4):269–270.

Kawakita A, Yanamoto S, Morishita K, Naruse T, Hayashida S, Soutome S, et al. Discontinuing oral bisphosphonate therapy during dental extraction does not prevent osteonecrosis of the jaw: A multicenter retrospective study of 341 patients with propensity score matching analysis. J Oral Maxillofac Surgery, Med Pathol [Internet]. 2017;2029(6):522–526. Available from:

Maeda CY, Da Mata PS, Cavalcanti DR, Martini Rodrigues SC, Marcucci M. Knowledge and Attitudes of Brazilian Dental Students About Bisphosphonate-Related Osteonecrosis of the Jaw. Oral Surg Oral Med Oral Pathol Oral Radiol [Internet]. 2018;23(12):342(12):3421–3426. Available from:

Franchi S, Brucoli M, Boffano P, Dosio C, Benech A. Medical students’ knowledge of Medication Related Osteonecrosis of the Jaw. J Stomatol Oral Maxillofac Surg [Internet]. 2019. (19)30250-2 Available from:

Escobedo M, García-Consuegra L, Junquera S, Olay S, Ascani G, Junquera L. Medication-related osteonecrosis of the jaw: A survey of knowledge, attitudes, and practices among dentists in the principality of Asturias (Spain). J Stomatol Oral Maxillofac Surg. 2018;119(5):395–400.

García-Martínez L, Martín-Payo R, Pelaz-García A, Sierra-Vega M, Junquera-Gutiérrez LM. Intervention to improve awareness of the risk factors for osteonecrosis of the jaw in patients under treatment with bisphosponates. Randomised clinical trial. Enfermería Clínica [Internet]. 2017;27(6):352–360. Available from:

Escobedo MF, Cobo JL, Junquera S, Milla J, Olay S, Junquera LM. Medication-related osteonecrosis of the jaw. Implant presence-triggered osteonecrosis: Case series and literature review. J Stomatol Oral Maxillofac Surg [Internet]. 2019;121(1):40–48. Available from:

Kishimoto H, Noguchi K, Takaoka K. Novel insight into the management of bisphosphonate-related osteonecrosis of the jaw (BRONJ). Jpn Dent Sci Rev [Internet]. 2019;55(1):95–102. Available from:

Tandon S, Lamba AK, Faraz F, Aggarwal K, Chowdhri K. A case report of bisphosphonate related osteonecrosis of the jaw treated by photodynamic therapy. Photodiagnosis Photodyn Ther [Internet]. 2019;26(April):313–315. Available from:

Nisi M, Karapetsa D, Gennai S, Ramaglia L, Graziani F, Gabriele M. Conservative surgical treatment of medication related osteonecrosis of the jaw (MRONJ) lesions in patients affected by osteoporosis exposed to oral bisphosphonates: 24 months follow-up. J Cranio-Maxillofacial Surg [Internet]. 2018;46(7):1153–1158. Available from:

Kim HY, Lee SJ, Kim SM, Myoung H, Hwang SJ, Choi JY, et al. Extensive Surgical Procedures Result in Better Treatment Outcomes for Bisphosphonate-Related Osteonecrosis of the Jaw in Patients With Osteoporosis. J Oral Maxillofac Surg [Internet]. 2017;75(7):1404–1413. Available from:

Nicolatou-Galitis O, Schiødt M, Mendes RA, Ripamonti C, Hope S, Drudge-Coates L, et al. Medication-related osteonecrosis of the jaw: definition and best practice for prevention, diagnosis, and treatment. Oral Surg Oral Med Oral Pathol Oral Radiol [Internet]. 2019;127(2):117–135. Available from:


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