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Immunohistochemistry have had a huge impact on oral and maxillofacial pathology diagnosis. As a method it determines distribution and amount of certain cellular molecules via specific antigen-antibody reaction. Whereas in most cases a definitive diagnosis is achieved based on detailed hematoxylin and eosin cytomorphological analysis, along with clinical and radiological features, some challenging and equivocal neoplasms need to be further assessed with immunohistochemistry. This article reviews immunohistochemistry technique fundamentals and its role and relevance in the diagnosis of common oral and maxillofacial lesions encountered in  daily practice.

Jairo Alberto Bustillo Rojas , Pontificia Universidad Javeriana, School of Dentistry, Department of Buccal System, Division of Pathology and Buccal Surgery, Bogotá, Colombia.

Pontificia Universidad Javeriana, School of Dentistry, Department of Buccal System, Division of Pathology and Buccal Surgery, Bogotá, Colombia.   

Guillermo Enrique Blanco Ballesteros, Universidad Estatal de Londrina, School of Dentistry, Department of Oral Medicine and Pediatric Dentistry, Division of Oral and Maxillofacial Radiology, Londrina, Brasil.

Universidad Estatal de Londrina, School of Dentistry, Department of Oral Medicine and Pediatric Dentistry, Division of Oral and Maxillofacial  Radiology, Londrina, Brasil.

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Received 2022-07-11
Accepted 2023-02-17
Published 2023-06-05