The effect of antiretroviral therapy on the oral and periodontal status of patients with hiv/aids: narrative review
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Patients with HIV have a decrease in CD4+ T cells, making them more susceptible to developing infections. Antiretroviral therapy (ART) decreases viral load and improves T-CD4 production. It has been suggested that periodontitis could decrease its prevalence due to the use of antiretrovirals.
Objective: To identify, through a literature review, the most recent and relevant evidence of patients with HIV and the effect of ART on oral and periodontal status.
Materials and Methods: A search for clinical articles was carried out in PubMed, Science Direct LILACS and Google Scholar, between the years 2011 and 2023. Selection criteria: patients with ART for HIV and evaluation of oral/periodontal status. Clinical trials, systematic reviews and meta-analyses were included.
Results: Initially, 173 articles were identified, 135 were excluded, finding in the end only two systematic reviews and no clinical trials. One systematic review presented 18 articles with 1632 adult patients with periodontal disease (PD) and highly active antiretroviral therapy (HAART) and the other in children with 12 articles and 1002 patients <18 years of age reviewing periodontal status and oral lesions.
Conclusion: HAART reduces the prevalence of oral manifestations in children with HIV; but not so with PD in adult patients with HAART, with the exception of necrotizing gingivitis.
Ntolou P, Pani P, Panis V, Madianos P, Vassilopoulos S. The effect of antiretroviral therapy on the periodontal conditions of patients with HIV infection: A systematic review and meta-analysis. J Clin Periodontol. 2023;50:170–82. DOI: 10.1111/jcpe.13735 DOI: https://doi.org/10.1111/jcpe.13735
Lam PPY, Zhou N, Wong HM, Yiu CKY. Oral Health Status of Children and Adolescents Living with HIV Undergoing Antiretroviral Therapy: A Systematic Review and Meta-Analysis. Int J Environ Res Public Health. 2022 Oct 8;19(19):12864. doi: 10.3390/ijerph191912864. PMID: 36232165; PMCID: PMC9564723. DOI: https://doi.org/10.3390/ijerph191912864
John CN, Stephen LX, Joyce Africa CW. Is human immunodeficiency virus (HIV) stage an independent risk factor for altering the periodontal status of HIV-positive patients? A South African study. BMC Oral Health. 2013 Dec 3;13:69. doi: 10.1186/1472-6831-13-69. PMID: 24295071; PMCID: PMC4219621. DOI: https://doi.org/10.1186/1472-6831-13-69
Rozra S, Kundu D, Saha B, Rudra A, Chakrabarty S, Bharati P. Periodontal status of HIV infected patients with special reference to CD4 cell count in West Bengal, India. Asian Pac J Trop Dis. 2012;2(6):470–4 https://doi.org/10.1016/S2222-1808(12)60102-9 . DOI: https://doi.org/10.1016/S2222-1808(12)60102-9
Qadir Saima, Naseem Nadia, Sami Waqas, Nagi Ah. Effect of antiretroviral therapy on oral lesions in hiv/aids. Pakistan Oral & Dental Journal. 2016; 86(8): p. 387-390. Disponible en https://www.researchgate.net/publication/308902971_EFFECT_OF_ANTIRETROVIRAL_THERAPY_ON_ORAL_LESIONS_IN_HIVAIDS
Nouaman MN, Meless DG, Coffie PA, Arrivé E, Tchounga BK, Ekouévi DK, Anoma C, Eholié SP, Dabis F, Jaquet A; IeDEA West Africa collaboration. Oral health and HIV infection among female sex workers in Abidjan, Côte d'Ivoire. BMC Oral Health. 2015 Dec 2;15(1):154. doi: 10.1186/s12903-015-0129-0. PMID: 26631015; PMCID: PMC4668627. DOI: https://doi.org/10.1186/s12903-015-0129-0
Tappuni AR, Fleming GJ. The effect of antiretroviral therapy on the prevalence of oral manifestations in HIV-infected patients: a UK study. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2001 Dec;92(6):623-8. doi: 10.1067/moe.2001.118902. PMID: 11740479. DOI: https://doi.org/10.1067/moe.2001.118902
Nicolatou-Galitis O, Velegraki A, Paikos S, Economopoulou P, Stefaniotis T, Papanikolaou IS, Kordossis T. Effect of PI-HAART on the prevalence of oral lesions in HIV-1 infected patients. A Greek study. Oral Dis. 2004 May;10(3):145-50. doi: 10.1046/j.1601-0825.2003.00994.x. PMID: 15089923. DOI: https://doi.org/10.1046/j.1601-0825.2003.00994.x
Hamza OJ, Matee MI, Simon EN, Kikwilu E, Moshi MJ, Mugusi F, Mikx FH, Verweij PE, van der Ven AJ. Oral manifestations of HIV infection in children and adults receiving highly active anti-retroviral therapy [HAART] in Dar es Salaam, Tanzania. BMC Oral Health. 2006 Aug 18;6:12. doi: 10.1186/1472-6831-6-12. PMID: 16916469; PMCID: PMC1559688. DOI: https://doi.org/10.1186/1472-6831-6-12
Eyeson JD, Tenant-Flowers M, Cooper DJ, Johnson NW, Warnakulasuriya KA. Oral manifestations of an HIV positive cohort in the era of highly active anti-retroviral therapy (HAART) in South London. J Oral Pathol Med. 2002 Mar;31(3):169-74. doi: 10.1034/j.1600-0714.2002.310308.x. PMID: 11903824. DOI: https://doi.org/10.1034/j.1600-0714.2002.310308.x
Brito A, Escalona LA, Correnti M, Perrone M, Bravo IM, Tovar V. Periodontal conditions and distribution of Prevotella intermedia, Porphyromonas gingivalis and Aggregatibacter actinomycetemcomitans in HIV-infected patients undergoing anti-retroviral therapy and in an HIV-seronegative group of the Venezuelan population. Acta Odontol Latinoam. 2008;21(1):89-96. PMID: 18841752.
Fricke U, Geurtsen W, Staufenbiel I, Rahman A. Periodontal status of HIV-infected patients undergoing antiretroviral therapy compared to HIV-therapy naive patients: a case control study. Eur J Med Res. 2012 Jan 30;17(1):2. doi: 10.1186/2047-783X-17-2. PMID: 22472296; PMCID: PMC3337541. DOI: https://doi.org/10.1186/2047-783X-17-2
Valentine J, Saladyanant T, Ramsey K, Blake J, Morelli T, Southerland J, Quinlivan EB, Phillips C, Nelson J, DeParis K, Webster-Cyriaque J. Impact of periodontal intervention on local inflammation, periodontitis, and HIV outcomes. Oral Dis. 2016 Apr;22 Suppl 1(Suppl 1):87-97. doi: 10.1111/odi.12419. PMID: 27109277; PMCID: PMC4899823. DOI: https://doi.org/10.1111/odi.12419
Souza AJ, Gomes-Filho IS, Silva CALD, Passos-Soares JS, Cruz SSD, Trindade SC, Figueiredo ACMG, Buischi YP, Seymour GJ, Cerqueira EMM. Factors associated with dental caries, periodontitis and intra-oral lesions in individuals with HIV / AIDS. AIDS Care. 2018 May;30(5):578-585. doi: 10.1080/09540121.2017.1400640. Epub 2017 Nov 10. PMID: 29124950. DOI: https://doi.org/10.1080/09540121.2017.1400640
Rao KV, Chitturi RT, Kattappagari KK, Kantheti LP, Poosarla C, Baddam VR. Impact of highly active antiretroviral therapy on oral manifestations of patients with human immunodeficiency virus/acquired immuno deficiency syndrome in South India. Indian J Sex Transm Dis AIDS. 2015 Jan-Jun;36(1):35-9. doi: 10.4103/0253-7184.156703. PMID: 26392652; PMCID: PMC4555897.. DOI: https://doi.org/10.4103/0253-7184.156703
Moodley, Adeshnee & Wood, Neil. HIV-Associated Oral Lesions in HIV-Seropositive Patients at an HIVTreatment Clinic in South Africa. Journal of AIDS & Clinical Research. 2015; 6(2): p. 422. DOI: 10.4172/2155-6113.1000422. DOI: https://doi.org/10.4172/2155-6113.1000422
Patil N, Chaurasia VR, Babaji P, Ramesh D, Jhamb K, Sharma AM. The effect of highly active antiretroviral therapy on the prevalence of oral manifestation in human immunodeficiency virus-infected patients in Karnataka, India. Eur J Dent. 2015 Jan-Mar;9(1):47-52. doi: 10.4103/1305-7456.149640. PMID: 25713484; PMCID: PMC4319299. DOI: https://doi.org/10.4103/1305-7456.149640
Mthethwa SR, Wanjau J, Chabikuli N. The prevalence of HIV associated oral lesions among adults in the era of HAART. SADJ. 2013 Sep;68(8):364-71. PMID: 24660404.
Khammissa R, Feller L, Altini M, Fatti P, Lemmer J. A Comparison of Chronic Periodontitis in HIV-Seropositive Subjects and the General Population in the Ga-Rankuwa Area, South Africa. AIDS Res Treat. 2012;2012:620962. doi: 10.1155/2012/620962. Epub 2012 Aug 29. PMID: 22970354; PMCID: PMC3434389. DOI: https://doi.org/10.1155/2012/620962
Sharma G, Pai KM, Suhas S, Ramapuram JT, Doshi D, Anup N. Oral manifestations in HIV/AIDS infected patients from India. Oral Dis. 2006 Nov;12(6):537-42. doi: 10.1111/j.1601-0825.2006.01232.x. PMID: 17054765. DOI: https://doi.org/10.1111/j.1601-0825.2006.01232.x
Baghirath PV, Krishna AB, Gannepalli A, Ali MM. Oral manifestations of HIV in children receiving anti-retroviral therapy in Hyderabad, India. Eur Arch Paediatr Dent. 2013 Dec;14(6):389-95. doi: 10.1007/s40368-013-0028-5. Epub 2013 Jun 13. PMID: 23760809.. DOI: https://doi.org/10.1007/s40368-013-0028-5
Bosco VL, Birman EG. Oral manifestations in children with AIDS and in controls. Pesqui Odontol Bras. 2002 Jan-Mar;16(1):7-11. doi: 10.1590/s1517-74912002000100002. Epub 2002 Jun 21. PMID: 11938722.. DOI: https://doi.org/10.1590/S1517-74912002000100002
Bosco VL, Birman EG, Cury AE, Paula CR. Yeasts from the oral cavity of children with AIDS: exoenzyme production and antifungal resistance. Pesqui Odontol Bras. 2003 Jul-Sep;17(3):217-22. doi: 10.1590/s1517-74912003000300004. Epub 2003 Dec 16. PMID: 14762498.. DOI: https://doi.org/10.1590/S1517-74912003000300004
Cerqueira DF, Portela MB, Pomarico L, de Araújo Soares RM, de Souza IP, Castro GF. Oral Candida colonization and its relation with predisposing factors in HIV-infected children and their uninfected siblings in Brazil: the era of highly active antiretroviral therapy. J Oral Pathol Med. 2010 Feb;39(2):188-94. doi: 10.1111/j.1600-0714.2009.00857.x. Epub 2009 Dec 22. PMID: 20040023. DOI: https://doi.org/10.1111/j.1600-0714.2009.00857.x
Divakar DD, Al Kheraif AA, Ramakrishnaiah R, Khan AA, Sandeepa NC, Alshahrani OA, et al. Oral manifestations in human immunodefi ciency virus infected pediatric patients receiving and not receiving antiretroviral therapy: A cross sectional study. Paediatria Croatica. 2015;59(3):152–8. DOI: http://dx.doi.org/10.13112/PC.2015.23 DOI: https://doi.org/10.13112/PC.2015.23
Pomarico L, Cerqueira DF, de Araujo Soares RM, de Souza IPR, de Araujo Castro GFB, Socransky S, et al. Associations among the use of highly active antiretroviral therapy, oral candidiasis, oral Candida species and salivary immunoglobulin A in HIV-infected children. Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology and Endodontology. 2009;108(2):203–10. DOI: https://doi.org/10.1016/j.tripleo.2009.05.008
Babu GK, Subramaniam P. Levels of Salivary Immunoglobulin A (SIgA) in HIV Infected Children [Internet]. Vol. 39, The Journal of Clinical Pediatric Dentistry. 2015. Disponible en: http://meridian.allenpress.com/jcpd/article-pdf/39/4/377/1744035/1053-4628-39_4_377.pdf DOI: https://doi.org/10.17796/1053-4628-39.4.377
Ponnam SR, Srivastava G, Theruru K. Oral manifestations of human immunodeficiency virus in children: An institutional study at highly active antiretroviral therapy centre in India. Journal of Oral and Maxillofacial Pathology. mayo de 2012;16(2):195–202. DOI: https://doi.org/10.4103/0973-029X.98499
- Sandra Amaya, Maria F. Bolaños, Adriana Jaramillo, Jorge E. Soto, Adolfo Contreras, Estado periodontal y microbiota subgingival en mujeres preeclámpticas , Revista Estomatología: Vol. 12 No. 2 (2004)
- Sandra Amaya, Maria Fernanda Bolaños, Adriana Jaramillo, Jorge Soto, Adolfo Contreras, Periodontal state and subgingival microbiota in preeclamptic women , Revista Estomatología: Vol. 13 No. 2 (2005)
- Jorge Soto, Mario Naicipa, Agrandamientos gingivales inducidos por drogas , Revista Estomatología: Vol. 5 No. 1 (1995)
- Lina Fernanda Urbano Muñoz , Kevin Andrés Cárdenas Pulido , Diana Marcela Hernández Lasso , Kelly Jhohana Orozco Domínguez , Jhoan León , Mónica Escudero , Sandra Amaya, Characterization of dental loss in patients treated in a teaching service clinic in the city of Cali – Colombia , Revista Estomatología: Vol. 32 No. 1 (2024)
Accepted 2024-09-23
Published 2024-10-30
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