Evolution of Explanatory Models of Periodontal Disease Pathogenesis


Summary: This review analyze
various periodontal disease pathogenesis models. The biological models that explain the pathogenesis
of the periodontal disease have presented an evolutionary change from 1960, when it was assumed that
only bacterial deposits caused the disease to nowdays. It is recently accepted that periodontal
disease is an infection that challenges the immune system and generates an inflammatory response
that affects the homeostasis of the periodontium. Additional factors like environment, genetics and
acquired factors also interact with the microbial milieu and the immune response to influence
disease progression. Key words: Periodontitis. Etiopathogenesis. Immunoinflamatory response. Biofilm
gingival interface. Genetic expression.


  • Ana Isabel Restrepo Universidad del Valle. Cali, Colombia.
  • Solange Velasco Universidad del Valle. Cali, Colombia.
  • Leonardo Franco Universidad del Valle. Cali, Colombia.


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Author Biographies

, Universidad del Valle. Cali, Colombia.

Estudiante Postgrado de Periodoncia, Escuela de Odontología.

, Universidad del Valle. Cali, Colombia.

Estudiante Postgrado de Ortodoncia, Escuela de Odontología.


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How to Cite
Restrepo, A. I., Velasco, S., & Franco, L. (2017). Evolution of Explanatory Models of Periodontal Disease Pathogenesis. Revista Estomatología, 17(2). https://doi.org/10.25100/re.v17i2.5700
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