TY - JOUR AU - Contreras Renjifo, Adolfo AU - León Berrios, Rubén AU - Castillo Giraldo, Andrés AU - Bahamon, José Luis AU - Giraldo, Yurani AU - Libreros Zúñiga, Gerardo Andrés AU - Contreras Parra, Alejandro AU - Gispert, Juan AU - Balanta- Melo, Julián AU - Alban, Fausto Andrés AU - Parra, Beatriz PY - 2023/06/05 Y2 - 2024/03/28 TI - A Mouthwash with Cetylpyridinium Chloride Is Reducing Salivary SARS-CoV-2 Viral Load in +COVID-19. JF - Revista Estomatología JA - Rev Estomatol VL - 31 IS - 1 SE - Original Articles DO - 10.25100/re.v31i1.12669 UR - https://estomatologia.univalle.edu.co/index.php/revista_estomatologia/article/view/12669 SP - AB - <p><strong>Aim</strong>: The aim of this randomised, double-blind, placebo-controlled pilot clinical trial is to evaluate the capacity of a mouthwash to reduce SARS-CoV-2 viral load in the saliva of patients with COVID-19.</p><p><strong>Methods</strong>: Twenty-three symptomatic SARS-CoV-2-positive outpatients were selected and randomised into two groups&nbsp; and registered at NTC 04563689. Both groups rinsed and gargled for one minute with either distilled water (Placebo) or with 0.05% Cetylpyridinium chloride (CPC) plus 0.12% Chlorhexidine (CHX) mouthwash (PERIOAID Intensive Care<sup>Ò</sup>). Saliva samples were collected before the use of placebo or mouthwash and after 15 minutes and 1 and 2 hours of either of the above treatment. A saliva sample was also taken five days after regular use of placebo or mouthwash twice daily. The virus was detected by qRT-PCR.</p><p><strong>Results</strong>: A great heterogeneity in the viral load values was observed at baseline in both groups for nasopharyngeal and saliva samples. Most of the patients who used the mouthwash (8/12) had a significant decrease in baseline viral load after 15 min (greater than 99% reduction). This inhibitory effect was maintained for up to two hours in 10 of the 12 patients. At five days, SARS-CoV-2 RNA was detected in only 1 patient from the mouthwash group and in 5 from the placebo group.</p><p><strong>Conclusions</strong>: This study points out that a CPC mouthwash can reduce the viral load in saliva of COVID-positive patients. This finding may be important in transmission control of SARS-CoV-2. Nevertheless, the clinical relevance of CPC mouthwash-reduction on SARS-CoV-2 shedding in saliva requires further study</p> ER -